Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis

SIMPLE SUMMARY: p53, a critical tumor suppressor, is commonly mutated in neoplasia, including colorectal cancer. To devise anti-cancer strategies targeting p53, it is crucial to understand the myriad cell-specific regulatory mechanisms in the p53 signaling pathway, and how these same regulatory mech...

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Detalles Bibliográficos
Autores principales: Lai, Chunwei W., Xie, Cindy, Raufman, Jean-Pierre, Xie, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750794/
https://www.ncbi.nlm.nih.gov/pubmed/35008383
http://dx.doi.org/10.3390/cancers14010219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750794/
https://www.ncbi.nlm.nih.gov/pubmed/35008383
http://dx.doi.org/10.3390/cancers14010219

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