Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1α ER Stress Signaling

Overdose of acetaminophen (APAP) can cause severe liver injury. Although alcohol is considered a risk factor for APAP toxicity, the mechanism underlying the interaction between alcohol and APAP remains unclear. Binge alcohol (5 g/kg every 12 h, 3 doses) reduced the concentration of cysteine and glut...

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Detalles Bibliográficos
Autores principales: Kim, Sou Hyun, Choi, Hun Ji, Seo, Hyeji, Kwon, Doyoung, Yun, Jaesuk, Jung, Young-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750905/
https://www.ncbi.nlm.nih.gov/pubmed/34943052
http://dx.doi.org/10.3390/antiox10121949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750905/
https://www.ncbi.nlm.nih.gov/pubmed/34943052
http://dx.doi.org/10.3390/antiox10121949

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