Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals

We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding a...

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Detalles Bibliográficos
Autores principales: Hemachudha, P., Petcharat, S., Ampoot, W., Ponpinit, T., Paitoonpong, L., Hemachudha, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750952/
https://www.ncbi.nlm.nih.gov/pubmed/35035981
http://dx.doi.org/10.1016/j.nmni.2022.100950
Descripción
Sumario:We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding and may also affect binding affinity for favipiravir.

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