Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals

We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding a...

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Autores principales: Hemachudha, P., Petcharat, S., Ampoot, W., Ponpinit, T., Paitoonpong, L., Hemachudha, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750952/
https://www.ncbi.nlm.nih.gov/pubmed/35035981
http://dx.doi.org/10.1016/j.nmni.2022.100950
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author Hemachudha, P.
Petcharat, S.
Ampoot, W.
Ponpinit, T.
Paitoonpong, L.
Hemachudha, T.
author_facet Hemachudha, P.
Petcharat, S.
Ampoot, W.
Ponpinit, T.
Paitoonpong, L.
Hemachudha, T.
author_sort Hemachudha, P.
collection PubMed
description We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding and may also affect binding affinity for favipiravir.
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spelling pubmed-87509522022-01-11 Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals Hemachudha, P. Petcharat, S. Ampoot, W. Ponpinit, T. Paitoonpong, L. Hemachudha, T. New Microbes New Infect Letter to the Editor We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding and may also affect binding affinity for favipiravir. Elsevier 2022-01-11 /pmc/articles/PMC8750952/ /pubmed/35035981 http://dx.doi.org/10.1016/j.nmni.2022.100950 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter to the Editor
Hemachudha, P.
Petcharat, S.
Ampoot, W.
Ponpinit, T.
Paitoonpong, L.
Hemachudha, T.
Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals
title Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals
title_full Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals
title_fullStr Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals
title_full_unstemmed Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals
title_short Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals
title_sort genetic variations from successive whole genome sequencing during covid-19 treatment in five individuals
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750952/
https://www.ncbi.nlm.nih.gov/pubmed/35035981
http://dx.doi.org/10.1016/j.nmni.2022.100950
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