Cargando…

Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

BACKGROUND: Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenerative diseases. We need highly efficient MN differentiation strategies for gener...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qian, Feng, Yi, Xue, Yingchao, Zhan, Xiping, Fu, Yi, Gui, Gege, Zhou, Weiqiang, Richard, Jean-Philippe, Taga, Arens, Li, Pan, Mao, Xiaobo, Maragakis, Nicholas J., Ying, Mingyao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751314/ https://www.ncbi.nlm.nih.gov/pubmed/35012575 http://dx.doi.org/10.1186/s13024-021-00510-y

Ejemplares similares

The RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells
por: Tang, Ming-Jer, et al.
Publicado: (1998)

Acute stress disrupts intestinal homeostasis via GDNF‐RET
por: Lin, Lin, et al.
Publicado: (2020)

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons
por: Xue, Yingchao, et al.
Publicado: (2018)

The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells
por: Li, Li, et al.
Publicado: (2017)

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential
por: Mulligan, Lois M.
Publicado: (2019)

RET-independent signaling by GDNF ligands and GFRα receptors
por: Ibáñez, Carlos F., et al.
Publicado: (2020)

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential
por: Yadav, Leena, et al.
Publicado: (2020)

The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system
por: Kramer, Edgar R.
Publicado: (2015)

Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification
por: Donnelly, Christopher R., et al.
Publicado: (2018)

Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction
por: Garton, Daniel R., et al.
Publicado: (2023)

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis
por: Lu, Benson, et al.
Publicado: (2009)

GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF-1/SREBP-1
por: Yu, Zhi-Yun, et al.
Publicado: (2022)

Edaravone Enhances Brain-Derived Neurotrophic Factor Production in the Ischemic Mouse Brain
por: Okuyama, Satoshi, et al.
Publicado: (2015)

Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
por: Drinkut, Anja, et al.
Publicado: (2016)

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons
por: Rhymes, Elena R., et al.
Publicado: (2022)

GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway
por: Mikroulis, Apostolos, et al.
Publicado: (2022)

The Role of Metals in the Neuroregenerative Action of BDNF, GDNF, NGF and Other Neurotrophic Factors
por: Nicoletti, Vincenzo Giuseppe, et al.
Publicado: (2022)

Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
por: Drinkut, Anja, et al.
Publicado: (2018)

Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons
por: Curcio, M, et al.
Publicado: (2015)

Serum glial cell line-derived neurotrophic factor (GDNF) a potential biomarker of executive function in Parkinson’s disease
por: Tong, Shu-Yan, et al.
Publicado: (2023)

Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits
por: García-Villamar, Verónica, et al.
Publicado: (2018)

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats
por: Wang, Xiaoyan, et al.
Publicado: (2023)

Mutation and deletion analysis of GFRα-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours
por: Gimm, O, et al.
Publicado: (1999)

Axon Guidance of Sympathetic Neurons to Cardiomyocytes by Glial Cell Line-Derived Neurotrophic Factor (GDNF)
por: Miwa, Keiko, et al.
Publicado: (2013)

Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a Novel Candidate Gene of Anxiety
por: Kotyuk, Eszter, et al.
Publicado: (2013)

The Influence of Neurotrophic Factors BDNF and GDNF Overexpression on the Functional State of Mice and Their Adaptation to Audiogenic Seizures
por: Kustova, Angelina O., et al.
Publicado: (2022)

Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic
por: Conway, James A., et al.
Publicado: (2021)

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
Publicado: (1995)

Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release
por: Zhang, Feng, et al.
Publicado: (2012)

MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression
por: Maheu, M, et al.
Publicado: (2015)

Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson’s Disease
por: Garea-Rodríguez, Enrique, et al.
Publicado: (2016)

Beyond iPS!
Publicado: (2012)

Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro
por: Saarenpää, Tuulia, et al.
Publicado: (2017)

GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1
por: Marks, Brooke A., et al.
Publicado: (2023)

History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair
por: Walker, Melissa J., et al.
Publicado: (2018)

The Role of Nerve Growth Factor (NGF) and Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Tic Disorders
por: Karayagmurlu, Ali, et al.
Publicado: (2018)

GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration
por: Vishlaghi, Neda, et al.
Publicado: (2022)

Aging in iPS cells
por: Miller, Justine, et al.
Publicado: (2014)

Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
por: Menshykau, Denis, et al.
Publicado: (2019)

Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning
por: Sergaki, Maria Christina, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_p65bj56ep8j8m0vna803obvn4q