Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

BACKGROUND: The mTOR-PI3K-Akt pathway influences cell metabolism and (malignant) cell growth. We generated sex-specific polygenic risk scores capturing natural variation in 7 out of 10 top-ranked genes in this pathway. We studied the scores directly and in interaction with energy balance-related fac...

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Detalles Bibliográficos
Autores principales: Simons, Colinda C.J.M., Schouten, Leo J., Godschalk, Roger W.L., van Schooten, Frederik-Jan, Stoll, Monika, Van Steen, Kristel, van den Brandt, Piet A., Weijenberg, Matty P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751328/
https://www.ncbi.nlm.nih.gov/pubmed/35012583
http://dx.doi.org/10.1186/s13040-021-00286-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751328/
https://www.ncbi.nlm.nih.gov/pubmed/35012583
http://dx.doi.org/10.1186/s13040-021-00286-3

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