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Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

BACKGROUND: The mTOR-PI3K-Akt pathway influences cell metabolism and (malignant) cell growth. We generated sex-specific polygenic risk scores capturing natural variation in 7 out of 10 top-ranked genes in this pathway. We studied the scores directly and in interaction with energy balance-related fac...

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Detalles Bibliográficos
Autores principales:	Simons, Colinda C.J.M., Schouten, Leo J., Godschalk, Roger W.L., van Schooten, Frederik-Jan, Stoll, Monika, Van Steen, Kristel, van den Brandt, Piet A., Weijenberg, Matty P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751328/ https://www.ncbi.nlm.nih.gov/pubmed/35012583 http://dx.doi.org/10.1186/s13040-021-00286-3

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