Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis

BACKGROUND: Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B‐cell lymphoproliferative disorders. Ibrutinib is associated with new‐onset atrial fibrillation. Cases of sinus bradycardia and sinus arrest have also been reported following ibrutinib treatment....

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Detalles Bibliográficos
Autores principales: Tuomi, Jari M., Bohne, Loryn J., Dorey, Tristan W., Jansen, Hailey J., Liu, Yingjie, Jones, Douglas L., Rose, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751944/
https://www.ncbi.nlm.nih.gov/pubmed/34726066
http://dx.doi.org/10.1161/JAHA.121.022369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751944/
https://www.ncbi.nlm.nih.gov/pubmed/34726066
http://dx.doi.org/10.1161/JAHA.121.022369

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