Reversion mutations in phosphoprotein P of a codon-pair-deoptimized human respiratory syncytial virus confer increased transcription, immunogenicity, and genetic stability without loss of attenuation

Recoding viral genomes by introducing numerous synonymous nucleotide substitutions that create suboptimal codon pairs provides new live-attenuated vaccine candidates. Because recoding typically involves a large number of nucleotide substitutions, the risk of de-attenuation is presumed to be low. How...

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Detalles Bibliográficos
Autores principales: Chen, Jessica W., Yang, Lijuan, Santos, Celia, Hassan, Sergio A., Collins, Peter L., Buchholz, Ursula J., Le Nouën, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751989/
https://www.ncbi.nlm.nih.gov/pubmed/34965283
http://dx.doi.org/10.1371/journal.ppat.1010191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751989/
https://www.ncbi.nlm.nih.gov/pubmed/34965283
http://dx.doi.org/10.1371/journal.ppat.1010191

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