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Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

Wnt signaling plays important roles in development, homeostasis, and tumorigenesis. Mutations in β-catenin that activate Wnt signaling have been found in colorectal and hepatocellular carcinomas. However, the dynamics of wild-type and mutant forms of β-catenin are not fully understood. Here, we geno...

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Detalles Bibliográficos
Autores principales: Ambrosi, Giulia, Voloshanenko, Oksana, Eckert, Antonia F, Kranz, Dominique, Nienhaus, G Ulrich, Boutros, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752093/
https://www.ncbi.nlm.nih.gov/pubmed/35014953
http://dx.doi.org/10.7554/eLife.64498