Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics

Xenobiotics can interact with cytochromes P450 (CYPs), resulting in drug–drug interactions, but CYPs can also contribute to drug–disease interactions, especially in the case of inflammation, which downregulates CYP activities through pretranscriptional and posttranscriptional mechanisms. Interleukin...

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Detalles Bibliográficos
Autores principales: Lenoir, Camille, Niederer, Amine, Rollason, Victoria, Desmeules, Jules Alexandre, Daali, Youssef, Samer, Caroline Flora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752107/
https://www.ncbi.nlm.nih.gov/pubmed/34791831
http://dx.doi.org/10.1002/psp4.12730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752107/
https://www.ncbi.nlm.nih.gov/pubmed/34791831
http://dx.doi.org/10.1002/psp4.12730

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