Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

As one of the key components in model‐informed drug discovery and development, physiologically‐based pharmacokinetic (PBPK) modeling linked with in vitro‐to‐in vivo extrapolation (IVIVE) is widely applied to quantitatively predict drug–drug interactions (DDIs) on drug‐metabolizing enzymes and transp...

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Detalles Bibliográficos
Autores principales: Yamazaki, Shinji, Evers, Raymond, De Zwart, Loeckie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752109/
https://www.ncbi.nlm.nih.gov/pubmed/34668334
http://dx.doi.org/10.1002/psp4.12733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752109/
https://www.ncbi.nlm.nih.gov/pubmed/34668334
http://dx.doi.org/10.1002/psp4.12733

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