Physiologically based pharmacokinetic modeling for dose optimization of quinine–phenobarbital coadministration in patients with cerebral malaria

Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions. The study aimed to predict the potential dose regimens of quin...

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Detalles Bibliográficos
Autores principales: Sae‐heng, Teerachat, Rajoli, Rajith Kumar Reddy, Siccardi, Marco, Karbwang, Juntra, Na‐Bangchang, Kesara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752110/
https://www.ncbi.nlm.nih.gov/pubmed/34730282
http://dx.doi.org/10.1002/psp4.12737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752110/
https://www.ncbi.nlm.nih.gov/pubmed/34730282
http://dx.doi.org/10.1002/psp4.12737

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