Cargando…

Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies

Cilia formation is essential for human life. One of the earliest events in the ciliogenesis program is the recruitment of tau-tubulin kinase 2 (TTBK2) by the centriole distal appendage component CEP164. Due to the lack of high-resolution structural information on this complex, it is unclear how it i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosa e Silva, Ivan, Binó, Lucia, Johnson, Christopher M., Rutherford, Trevor J., Neuhaus, David, Andreeva, Antonina, Čajánek, Lukáš, van Breugel, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752127/ https://www.ncbi.nlm.nih.gov/pubmed/34499853 http://dx.doi.org/10.1016/j.str.2021.08.007

Ejemplares similares

Cep164, but not EB1, is critical for centriolar localization of TTBK2 and its function in ciliogenesis
por: Oda, Toshiaki, et al.
Publicado: (2015)

Embryonic and foetal expression patterns of the ciliopathy gene CEP164
por: Devlin, L. A., et al.
Publicado: (2020)

The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase
por: Al-Jassar, Caezar, et al.
Publicado: (2017)

Biallelic variants in CEP164 cause a motile ciliopathy‐like syndrome
por: Devlin, Laura A., et al.
Publicado: (2022)

Structural validation and assessment of AlphaFold2 predictions for centrosomal and centriolar proteins and their complexes
por: van Breugel, Mark, et al.
Publicado: (2022)

Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation
por: Lo, Chien-Hui, et al.
Publicado: (2019)

A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies
por: Shaheen, Ranad, et al.
Publicado: (2015)

Aggresome assembly at the centrosome is driven by CP110–CEP97–CEP290 and centriolar satellites
por: Prosser, Suzanna L., et al.
Publicado: (2022)

The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium
por: Stowe, Timothy R., et al.
Publicado: (2012)

Role of CSPP-L in recruitment of ciliopathy proteins to centriolar satellites and the ciliary transition zone
por: Patzke, S, et al.
Publicado: (2012)

Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis
por: Joseph, Nimesh, et al.
Publicado: (2018)

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
por: Bashore, Frances M., et al.
Publicado: (2023)

CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells
por: Kobayashi, Tetsuo, et al.
Publicado: (2020)

CEP164C regulates flagellum length in stable flagella
por: Atkins, Madison, et al.
Publicado: (2020)

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes
por: Binó, Lucia, et al.
Publicado: (2023)

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration
por: Taylor, Laura M., et al.
Publicado: (2018)

Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models
por: Corral-Serrano, Julio C., et al.
Publicado: (2023)

Eupatilin improves cilia defects in human CEP290 ciliopathy models
por: Corral-Serrano, JC, et al.
Publicado: (2023)

Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins
por: Rachel, Rivka A, et al.
Publicado: (2012)

Mutations in CEP120 cause Joubert syndrome as well as complex ciliopathy phenotypes
por: Roosing, Susanne, et al.
Publicado: (2016)

CSPP-L and EB3 localize to centriolar satellites and are required for satellite-dependent recruitment of ciliopathy proteins to the centrosome
por: Sternemalm, J, et al.
Publicado: (2015)

A novel pathogenic variant of CEP164 in an infant with Senior‐Loken syndrome
por: Liu, Lili, et al.
Publicado: (2023)

The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone
por: Klinger, Maren, et al.
Publicado: (2014)

CEP90 Is Required for the Assembly and Centrosomal Accumulation of Centriolar Satellites, Which Is Essential for Primary Cilia Formation
por: Kim, Kyeongmi, et al.
Publicado: (2012)

Cep164, a novel centriole appendage protein required for primary cilium formation
por: Graser, Susanne, et al.
Publicado: (2007)

Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
por: Schmidt, Kerstin N., et al.
Publicado: (2012)

Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development
por: Powell, L., et al.
Publicado: (2020)

Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
por: Fernius, Josefin, et al.
Publicado: (2017)

The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly
por: Le Borgne, Pierrick, et al.
Publicado: (2022)

Nephronophthisis-Associated CEP164 Regulates Cell Cycle Progression, Apoptosis and Epithelial-to-Mesenchymal Transition
por: Slaats, Gisela G., et al.
Publicado: (2014)

Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interrupts ciliary intraflagellar transport (IFT)
por: Reed, Michelle, et al.
Publicado: (2022)

Centriolar inequality
por: LeBrasseur, Nicole
Publicado: (2007)

Characterising a novel mouse model with a mutated ciliopathy gene (Cep290) leading to Joubert Syndrome
por: Hynes, AM, et al.
Publicado: (2012)

Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP290
por: Potter, Valencia L., et al.
Publicado: (2021)

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly
por: Liu, Yi, et al.
Publicado: (2018)

TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation
por: Liao, Jung-Chi, et al.
Publicado: (2015)

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation
por: Siller, Saul S., et al.
Publicado: (2017)

The structure and function of centriolar rootlets
por: Mahen, Robert
Publicado: (2021)

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons
por: Bowie, Emily, et al.
Publicado: (2020)

TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins
por: Nguyen, Abraham, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c41iqna1drbghl9iikpt5gifjo