Cargando…

G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure

AIMS : Myocardial infarction (MI) is the most common cause of heart failure (HF) worldwide. G protein-coupled receptor kinase 5 (GRK5) is upregulated in failing human myocardium and promotes maladaptive cardiac hypertrophy in animal models. However, the role of GRK5 in ischemic heart disease is stil...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Lucia, Claudio, Grisanti, Laurel A, Borghetti, Giulia, Piedepalumbo, Michela, Ibetti, Jessica, Lucchese, Anna Maria, Barr, Eric W, Roy, Rajika, Okyere, Ama Dedo, Murphy, Haley Christine, Gao, Erhe, Rengo, Giuseppe, Houser, Steven R, Tilley, Douglas G, Koch, Walter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752360/ https://www.ncbi.nlm.nih.gov/pubmed/33560342 http://dx.doi.org/10.1093/cvr/cvab044

Ejemplares similares

GRK5 is a regulator of fibroblast activation and cardiac fibrosis
por: Eguchi, Akito, et al.
Publicado: (2021)

Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels
por: Marzano, Federica, et al.
Publicado: (2022)

Leukocyte-Dependent Regulation of Cardiac Fibrosis
por: Okyere, Ama Dedo, et al.
Publicado: (2020)

Targeting GRK5 for Treating Chronic Degenerative Diseases
por: Marzano, Federica, et al.
Publicado: (2021)

GRK2 blockade with βARKct is essential for cardiac β(2)-adrenergic receptor signaling towards increased contractility
por: Salazar, Norma C, et al.
Publicado: (2013)

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
por: Maning, Jennifer, et al.
Publicado: (2020)

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
por: Inagaki, Sayaka, et al.
Publicado: (2015)

Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts
por: Carter, Rhonda L, et al.
Publicado: (2014)

Dual role of GRK5 in cancer development and progression
por: Gambardella, J, et al.
Publicado: (2016)

Effect of the 5-HT(4) receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract
por: Nedi, Teshome, et al.
Publicado: (2018)

GRK5 Is Associated with the Regulation of Methadone Dosage in Heroin Dependence
por: Wang, Sheng-Chang, et al.
Publicado: (2018)

Downregulation of GRK5 hampers the migration of breast cancer cells
por: Sommer, Ann-Katrin, et al.
Publicado: (2019)

Location-specific and Kinase-Independent GRK5 Function in Heart
por: Wang, Yifan F., et al.
Publicado: (2022)

Correction: Maning et al. Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition. Int. J. Mol. Sci. 2020, 21, 2868
por: Maning, Jennifer, et al.
Publicado: (2021)

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
por: Grisanti, Laurel A., et al.
Publicado: (2018)

GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice
por: Li, Longxuan, et al.
Publicado: (2008)

GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders
por: Hendrickx, Jhana O., et al.
Publicado: (2018)

Metabolomics, heart disease and aging
por: Piedepalumbo, Michela, et al.
Publicado: (2021)

Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging
por: de Lucia, Claudio, et al.
Publicado: (2020)

Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure
por: Kang, Sheng, et al.
Publicado: (2015)

GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability
por: He, Minchao, et al.
Publicado: (2016)

The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5
por: Lessel, Davor, et al.
Publicado: (2016)

GRK5 functions as an oncogenic factor in non-small-cell lung cancer
por: Jiang, Li-Ping, et al.
Publicado: (2018)

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
por: Reichel, Mona, et al.
Publicado: (2022)

Designer Approaches for G Protein–Coupled Receptor Modulation for Cardiovascular Disease
por: Grisanti, Laurel A., et al.
Publicado: (2018)

GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone
por: Pollard, Celina M, et al.
Publicado: (2022)

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
por: Møller, Thor C., et al.
Publicado: (2020)

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells
por: Stoeber, Miriam, et al.
Publicado: (2020)

Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
por: Garikipati, Venkata Naga Srikanth, et al.
Publicado: (2020)

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
por: Garikipati, Venkata Naga Srikanth, et al.
Publicado: (2019)

MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis
por: Zhong, Chao, et al.
Publicado: (2021)

A Dual Role for Death Receptor 5 in Regulating Cardiac Fibroblast Function
por: Tanner, Miles A., et al.
Publicado: (2021)

Nintedanib Regulates GRK2 and CXCR2 to Reduce Neutrophil Recruitment in Endotoxin-Induced Lung Injury
por: Su, Vincent Yi-Fong, et al.
Publicado: (2021)

GRK5 polymorphisms and Postoperative Atrial Fibrillation following Coronary Artery Bypass Graft Surgery
por: Liu, Lu, et al.
Publicado: (2015)

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal
por: Pham, Thao, et al.
Publicado: (2020)

Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway
por: Fan, Qian, et al.
Publicado: (2013)

Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice
por: Hoffman, Matthew, et al.
Publicado: (2019)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis
por: Chen, Yuejun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_30vv4d44803k6l9k94gg76k80g