Cargando…

Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides

Mutations in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein lead to persistent lung bacterial infections, mainly due to Pseudomonas aeruginosa, causing loss of respiratory function and finally death of people affected by CF. Unfortunately, even in the era of CFTR modulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrera, Loretta, Cappiello, Floriana, Loffredo, Maria Rosa, Puglisi, Elena, Casciaro, Bruno, Botta, Bruno, Galietta, Luis J. V., Mori, Mattia, Mangoni, Maria Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752549/ https://www.ncbi.nlm.nih.gov/pubmed/34971429 http://dx.doi.org/10.1007/s00018-021-04030-2

Ejemplares similares

Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases
por: Cappiello, Floriana, et al.
Publicado: (2022)

Antipseudomonal and Immunomodulatory Properties of Esc Peptides: Promising Features for Treatment of Chronic Infectious Diseases and Inflammation
por: Cappiello, Floriana, et al.
Publicado: (2021)

Bronchial epithelium repair by Esculentin-1a-derived antimicrobial peptides: involvement of metalloproteinase-9 and interleukin-8, and evaluation of peptides’ immunogenicity
por: Cappiello, Floriana, et al.
Publicado: (2019)

The antimicrobial peptide Esc(1-21)-1c increases susceptibility of Pseudomonas aeruginosa to conventional antibiotics by decreasing the expression of the MexAB-OprM efflux pump
por: Canè, Carolina, et al.
Publicado: (2023)

Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities
por: Casciaro, Bruno, et al.
Publicado: (2020)

The Antimicrobial Peptide Temporin G: Anti-Biofilm, Anti-Persister Activities, and Potentiator Effect of Tobramycin Efficacy Against Staphylococcus aureus
por: Casciaro, Bruno, et al.
Publicado: (2020)

Promising Approaches to Optimize the Biological Properties of the Antimicrobial Peptide Esculentin-1a(1–21)NH(2): Amino Acids Substitution and Conjugation to Nanoparticles
por: Casciaro, Bruno, et al.
Publicado: (2017)

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections
por: Casciaro, Bruno, et al.
Publicado: (2019)

The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria
por: Casciaro, Bruno, et al.
Publicado: (2022)

The Antimicrobial Peptide Esc(1-21) Synergizes with Colistin in Inhibiting the Growth and in Killing Multidrug Resistant Acinetobacter baumannii Strains
por: Sacco, Federica, et al.
Publicado: (2022)

KDEON WK-11: A short antipseudomonal peptide with promising potential
por: Casciaro, Bruno, et al.
Publicado: (2022)

The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
por: Cappiello, Floriana, et al.
Publicado: (2020)

Development of Antimicrobial Peptides from Amphibians
por: Mangoni, Maria Luisa, et al.
Publicado: (2020)

Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs
por: Bellavita, Rosa, et al.
Publicado: (2020)

Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections
por: Casciaro, Bruno, et al.
Publicado: (2020)

Novel Peptides with Dual Properties for Treating Pseudomonas aeruginosa Keratitis: Antibacterial and Corneal Wound Healing
por: Cappiello, Floriana, et al.
Publicado: (2023)

Synthetic Amphipathic β-Sheet Temporin-Derived Peptide with Dual Antibacterial and Anti-Inflammatory Activities
por: Bellavita, Rosa, et al.
Publicado: (2022)

ent-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors
por: Quaglio, Deborah, et al.
Publicado: (2020)

A novel colistin adjuvant identified by virtual screening for ArnT inhibitors
por: Ghirga, Francesca, et al.
Publicado: (2020)

Derivatives of Esculentin-1 Peptides as Promising Candidates for Fighting Infections from Escherichia coli O157:H7
por: Scotti, Raffaella, et al.
Publicado: (2022)

Editorial: Secondary Metabolites and Peptides as Unique Natural Reservoirs of New Therapeutic Leads for Treatment of Cancer and Microbial Infections
por: Mangoni, Maria Luisa, et al.
Publicado: (2021)

Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect on Candida albicans Virulence Factors
por: D’Auria, Felicia Diodata, et al.
Publicado: (2022)

Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations
por: Pedemonte, Nicoletta, et al.
Publicado: (2011)

The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH(2) Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent Manner: A Novel Promoter of Human Skin Wound Healing?
por: Di Grazia, Antonio, et al.
Publicado: (2015)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Allelic Variants Relate to Shifts in Faecal Microbiota of Cystic Fibrosis Patients
por: Schippa, Serena, et al.
Publicado: (2013)

Rapid Assessment of Susceptibility of Bacteria and Erythrocytes to Antimicrobial Peptides by Single-Cell Impedance Cytometry
por: Troiano, Cassandra, et al.
Publicado: (2023)

Correction: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Allelic Variants Relate to Shifts in Faecal Microbiota of Cystic Fibrosis Patients
por: Schippa, Serena, et al.
Publicado: (2013)

Glycosylation and the cystic fibrosis transmembrane conductance regulator
por: Scanlin, Thomas F, et al.
Publicado: (2001)

Where Is the Cystic Fibrosis Transmembrane Conductance Regulator?
por: Barbry, Pascal, et al.
Publicado: (2021)

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore
por: Wang, Wuyang, et al.
Publicado: (2011)

Acquired cystic fibrosis transmembrane conductance regulator dysfunction
por: Banks, Catherine, et al.
Publicado: (2018)

Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator
por: Villamizar, Olga, et al.
Publicado: (2019)

First-in-Class Cyclic Temporin L Analogue: Design, Synthesis, and Antimicrobial Assessment
por: Bellavita, Rosa, et al.
Publicado: (2021)

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink
por: Schramma, Kelsey R., et al.
Publicado: (2015)

Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives
por: Schmidt, Béla Z, et al.
Publicado: (2016)

The Extrapulmonary Effects of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Cystic Fibrosis
por: Sergeev, Valentine, et al.
Publicado: (2020)

Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator
por: Kleizen, Bertrand, et al.
Publicado: (2023)

Vasoactive intestinal peptide and cystic fibrosis transmembrane conductance regulator contribute to the transepithelial calcium transport across intestinal epithelium-like Caco-2 monolayer
por: Rodrat, Mayuree, et al.
Publicado: (2022)

Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
por: Botta, Joaquín, et al.
Publicado: (2019)

Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance
por: Rusnati, Marco, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9ihtnb55foglu170f8ukls4bt3