BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1

Defects in BRCA1, BRCA2 and other genes of the homology-dependent DNA repair (HR) pathway cause an elevated rate of mutagenesis, eliciting specific mutation patterns including COSMIC signature SBS3. Using genome sequencing of knock-out cell lines we show that Y family translesion synthesis (TLS) pol...

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Detalles Bibliográficos
Autores principales: Chen, Dan, Gervai, Judit Z., Póti, Ádám, Németh, Eszter, Szeltner, Zoltán, Szikriszt, Bernadett, Gyüre, Zsolt, Zámborszky, Judit, Ceccon, Marta, d’Adda di Fagagna, Fabrizio, Szallasi, Zoltan, Richardson, Andrea L., Szüts, Dávid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752635/
https://www.ncbi.nlm.nih.gov/pubmed/35017534
http://dx.doi.org/10.1038/s41467-021-27872-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752635/
https://www.ncbi.nlm.nih.gov/pubmed/35017534
http://dx.doi.org/10.1038/s41467-021-27872-7

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