DeepNull models non-linear covariate effects to improve phenotypic prediction and association power

Genome-wide association studies (GWASs) examine the association between genotype and phenotype while adjusting for a set of covariates. Although the covariates may have non-linear or interactive effects, due to the challenge of specifying the model, GWAS often neglect such terms. Here we introduce D...

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Detalles Bibliográficos
Autores principales: McCaw, Zachary R., Colthurst, Thomas, Yun, Taedong, Furlotte, Nicholas A., Carroll, Andrew, Alipanahi, Babak, McLean, Cory Y., Hormozdiari, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752755/
https://www.ncbi.nlm.nih.gov/pubmed/35017556
http://dx.doi.org/10.1038/s41467-021-27930-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752755/
https://www.ncbi.nlm.nih.gov/pubmed/35017556
http://dx.doi.org/10.1038/s41467-021-27930-0

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