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The RNA methyltransferase METTL8 installs m(3)C(32) in mitochondrial tRNAs(Thr/Ser(UCN)) to optimise tRNA structure and mitochondrial translation
Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m(3)C(32) in the human mitochondrial (mt-)tRNA(Thr) and mt-tRNA(Ser(UCN)). METTL8 crossli...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752778/ https://www.ncbi.nlm.nih.gov/pubmed/35017528 http://dx.doi.org/10.1038/s41467-021-27905-1 |