The RNA methyltransferase METTL8 installs m(3)C(32) in mitochondrial tRNAs(Thr/Ser(UCN)) to optimise tRNA structure and mitochondrial translation

Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m(3)C(32) in the human mitochondrial (mt-)tRNA(Thr) and mt-tRNA(Ser(UCN)). METTL8 crossli...

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Detalles Bibliográficos
Autores principales: Kleiber, Nicole, Lemus-Diaz, Nicolas, Stiller, Carina, Heinrichs, Marleen, Mai, Mandy Mong-Quyen, Hackert, Philipp, Richter-Dennerlein, Ricarda, Höbartner, Claudia, Bohnsack, Katherine E., Bohnsack, Markus T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752778/
https://www.ncbi.nlm.nih.gov/pubmed/35017528
http://dx.doi.org/10.1038/s41467-021-27905-1

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