Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is an aggressive pediatric tumor with a poor prognosis for metastasis and recurrent disease. Large-scale sequencing endeavors demonstrate that Rhabdomyosarcomas have a dearth of precisely targetable driver mutations. However, IGF-2 signaling is known to be grossly altered in R...

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Detalles Bibliográficos
Autores principales: Khurshid, Safiya, Montes, Matias, Comiskey, Daniel F., Shane, Brianne, Matsa, Eleftheria, Jung, Francesca, Brown, Chelsea, Bid, Hemant Kumar, Wang, Ruoning, Houghton, Peter J., Roberts, Ryan, Rigo, Frank, Chandler, Dawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752779/
https://www.ncbi.nlm.nih.gov/pubmed/35017650
http://dx.doi.org/10.1038/s41698-021-00245-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752779/
https://www.ncbi.nlm.nih.gov/pubmed/35017650
http://dx.doi.org/10.1038/s41698-021-00245-5

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