Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site

Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer-(OSE)-mediated gating of the active MYC to the nuclear pore in a poorly understood process. We show here that the principal tenet of the WNT-regulated MYC gating, facilitating nuclear export of...

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Detalles Bibliográficos
Autores principales: Chachoua, Ilyas, Tzelepis, Ilias, Dai, Hao, Lim, Jia Pei, Lewandowska-Ronnegren, Anna, Casagrande, Felipe Beccaria, Wu, Shuangyang, Vestlund, Johanna, Mallet de Lima, Carolina Diettrich, Bhartiya, Deeksha, Scholz, Barbara A., Martino, Mirco, Mehmood, Rashid, Göndör, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752836/
https://www.ncbi.nlm.nih.gov/pubmed/35017527
http://dx.doi.org/10.1038/s41467-021-27868-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752836/
https://www.ncbi.nlm.nih.gov/pubmed/35017527
http://dx.doi.org/10.1038/s41467-021-27868-3

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