Structural basis of BAK activation in mitochondrial apoptosis initiation

BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK threshold in membr...

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Detalles Bibliográficos
Autores principales: Singh, Geetika, Guibao, Cristina D., Seetharaman, Jayaraman, Aggarwal, Anup, Grace, Christy R., McNamara, Dan E., Vaithiyalingam, Sivaraja, Waddell, M. Brett, Moldoveanu, Tudor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752837/
https://www.ncbi.nlm.nih.gov/pubmed/35017502
http://dx.doi.org/10.1038/s41467-021-27851-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752837/
https://www.ncbi.nlm.nih.gov/pubmed/35017502
http://dx.doi.org/10.1038/s41467-021-27851-y

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