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Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin

In epithelia, normal cells recognize and extrude out newly emerged transformed cells by competition. This process is the most fundamental epithelial defence against cancer, whose occasional failure promotes oncogenesis. However, little is known about what factors determine the success or failure of...

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Detalles Bibliográficos
Autores principales: Pothapragada, Shilpa P., Gupta, Praver, Mukherjee, Soumi, Das, Tamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752856/
https://www.ncbi.nlm.nih.gov/pubmed/35017535
http://dx.doi.org/10.1038/s41467-021-27896-z