Critical assessment of structure-based approaches to improve protein resistance in aqueous ionic liquids by enzyme-wide saturation mutagenesis

Ionic liquids (IL) and aqueous ionic liquids (aIL) are attractive (co-)solvents for green industrial processes involving biocatalysts, but often reduce enzyme activity. Experimental and computational methods are applied to predict favorable substitution sites and, most often, subsequent site-directe...

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Detalles Bibliográficos
Autores principales: El Harrar, Till, Davari, Mehdi D., Jaeger, Karl-Erich, Schwaneberg, Ulrich, Gohlke, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752993/
https://www.ncbi.nlm.nih.gov/pubmed/35070165
http://dx.doi.org/10.1016/j.csbj.2021.12.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752993/
https://www.ncbi.nlm.nih.gov/pubmed/35070165
http://dx.doi.org/10.1016/j.csbj.2021.12.018

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