Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes

We design a “wisdom-of-the-crowds” GRN inference pipeline and couple it to complex network analysis to understand the organizational principles governing gene regulation in long-lived glp-1/Notch Caenorhabditis elegans. The GRN has three layers (input, core, and output) and is topologically equivale...

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Detalles Bibliográficos
Autores principales: Suriyalaksh, Manusnan, Raimondi, Celia, Mains, Abraham, Segonds-Pichon, Anne, Mukhtar, Shahzabe, Murdoch, Sharlene, Aldunate, Rebeca, Krueger, Felix, Guimerà, Roger, Andrews, Simon, Sales-Pardo, Marta, Casanueva, Olivia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753122/
https://www.ncbi.nlm.nih.gov/pubmed/35036864
http://dx.doi.org/10.1016/j.isci.2021.103663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753122/
https://www.ncbi.nlm.nih.gov/pubmed/35036864
http://dx.doi.org/10.1016/j.isci.2021.103663

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