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Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes

We design a “wisdom-of-the-crowds” GRN inference pipeline and couple it to complex network analysis to understand the organizational principles governing gene regulation in long-lived glp-1/Notch Caenorhabditis elegans. The GRN has three layers (input, core, and output) and is topologically equivale...

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Detalles Bibliográficos
Autores principales:	Suriyalaksh, Manusnan, Raimondi, Celia, Mains, Abraham, Segonds-Pichon, Anne, Mukhtar, Shahzabe, Murdoch, Sharlene, Aldunate, Rebeca, Krueger, Felix, Guimerà, Roger, Andrews, Simon, Sales-Pardo, Marta, Casanueva, Olivia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753122/ https://www.ncbi.nlm.nih.gov/pubmed/35036864 http://dx.doi.org/10.1016/j.isci.2021.103663

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