Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells

Oxidative stress, inflammation, and aberrant activation of microglia in the retina are commonly observed in ocular pathologies. In glaucoma or age-related macular degeneration, the chronic activation of microglia affects retinal ganglion cells and photoreceptors, respectively, contributing to gradua...

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Detalles Bibliográficos
Autores principales: Saada, Jamal, McAuley, Ryan J., Marcatti, Michela, Tang, Tony Zifeng, Motamedi, Massoud, Szczesny, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753185/
https://www.ncbi.nlm.nih.gov/pubmed/34953858
http://dx.doi.org/10.1016/j.jbc.2021.101523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753185/
https://www.ncbi.nlm.nih.gov/pubmed/34953858
http://dx.doi.org/10.1016/j.jbc.2021.101523

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