TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes

Decrease in DNA dioxygenase activity generated by TET2 gene family is crucial in myelodysplastic syndromes (MDS). The general downregulation of 5-hydroxymethylcytosine (5-hmC) argues for a role of DNA demethylation in MDS beyond TET2 mutations, which albeit frequent, do not convey any prognostic sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Gurnari, Carmelo, Pagliuca, Simona, Guan, Yihong, Adema, Vera, Hershberger, Courtney E., Ni, Ying, Awada, Hassan, Kongkiatkamon, Sunisa, Zawit, Misam, Coutinho, Diego F., Zalcberg, Ilana R., Ahn, Jae-Sook, Kim, Hyeoung-Joon, Kim, Dennis Dong Hwan, Minden, Mark D., Jansen, Joop H., Meggendorfer, Manja, Haferlach, Claudia, Jha, Babal K., Haferlach, Torsten, Maciejewski, Jaroslaw P., Visconte, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753204/
https://www.ncbi.nlm.nih.gov/pubmed/34768283
http://dx.doi.org/10.1182/bloodadvances.2021005418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753204/
https://www.ncbi.nlm.nih.gov/pubmed/34768283
http://dx.doi.org/10.1182/bloodadvances.2021005418

Ejemplares similares