Iron status influences the response of cord blood megakaryocyte progenitors to eltrombopag in vitro

Eltrombopag (ELT) is a thrombopoietic agent approved for immune thrombocytopenia and also a potent iron chelator. Here we found that ELT exhibited dose-dependent opposing effects on in vitro megakaryopoiesis: low concentrations (≤6 µM, ELT6) stimulated megakaryopoiesis, but high concentrations (30 µ...

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Detalles Bibliográficos
Autores principales: Liu, Zhi-Jian, Deschmann, Emoke, Ramsey, Haley E., Feldman, Henry A., Psaila, Bethan, Cooper, Nichola, Vlachodimitropoulou, Evangelia, Porter, John, Bussel, James, Georgieff, Michael, Sola-Visner, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753208/
https://www.ncbi.nlm.nih.gov/pubmed/34654056
http://dx.doi.org/10.1182/bloodadvances.2021004207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753208/
https://www.ncbi.nlm.nih.gov/pubmed/34654056
http://dx.doi.org/10.1182/bloodadvances.2021004207

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