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Assessment of HLA-B genetic variation with an HLA-B leader tool and implications in clinical transplantation

Sequence variation in the HLA-B gene is critically linked to differential immune responses. A dimorphism at -21 of HLA-B exon 1 gives rise to leader peptides that are markers for risk of acute graft-versus-host disease, relapse, and mortality after unrelated donor and cord blood transplantation. To...

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Detalles Bibliográficos
Autores principales:	Sajulga, Ray, Bolon, Yung-Tsi, Maiers, Martin J., Petersdorf, Effie W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753210/ https://www.ncbi.nlm.nih.gov/pubmed/34529780 http://dx.doi.org/10.1182/bloodadvances.2021004561

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