JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β

Development of normal blood cells is often suppressed in juvenile myelomonocytic leukemia (JMML), a myeloproliferative neoplasm (MPN) of childhood, causing complications and impacting therapeutic outcomes. However, the mechanism underlying this phenomenon remains uncharacterized. To address this que...

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Detalles Bibliográficos
Autores principales: Yan, Yuhan, Dong, Lei, Chen, Chao, Bunting, Kevin D., Li, Qianjin, Stieglitz, Elliot, Loh, Mignon L., Qu, Cheng-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753218/
https://www.ncbi.nlm.nih.gov/pubmed/34555844
http://dx.doi.org/10.1182/bloodadvances.2021005089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753218/
https://www.ncbi.nlm.nih.gov/pubmed/34555844
http://dx.doi.org/10.1182/bloodadvances.2021005089

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