CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy

Fibroblasts can be reprogrammed into cardiovascular progenitor cells (CPCs) using transgenic approaches, although the underlying mechanism remains unclear. We determined whether activation of endogenous genes such as Gata4, Nkx2.5, and Tbx5 can rapidly establish autoregulatory loops and initiate CPC...

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Detalles Bibliográficos
Autores principales: Jiang, Lin, Liang, Jialiang, Huang, Wei, Ma, Jianyong, Park, Ki Ho, Wu, Zhichao, Chen, Peng, Zhu, Hua, Ma, Jian-Jie, Cai, Wenfeng, Paul, Christian, Niu, Liang, Fan, Guo-Chang, Wang, Hong-Sheng, Kanisicak, Onur, Xu, Meifeng, Wang, Yigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753567/
https://www.ncbi.nlm.nih.gov/pubmed/34678511
http://dx.doi.org/10.1016/j.ymthe.2021.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753567/
https://www.ncbi.nlm.nih.gov/pubmed/34678511
http://dx.doi.org/10.1016/j.ymthe.2021.10.015

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