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Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors
BACKGROUND: Little is known about depression and anxiety among paediatric intracranial germ cell tumour (iGCT) survivors. We aimed to evaluate the risk factors associated with depression, anxiety and health-related quality of life (HRQoL) in paediatric iGCT survivors. METHODS: We recruited 200 iGCT...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753919/ https://www.ncbi.nlm.nih.gov/pubmed/35022038 http://dx.doi.org/10.1186/s12955-021-01911-9 |
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author | Lv, Wenyi Li, Bo Feng, Jin Chen, Li Qiu, Xiaoguang Liu, Shuai |
author_facet | Lv, Wenyi Li, Bo Feng, Jin Chen, Li Qiu, Xiaoguang Liu, Shuai |
author_sort | Lv, Wenyi |
collection | PubMed |
description | BACKGROUND: Little is known about depression and anxiety among paediatric intracranial germ cell tumour (iGCT) survivors. We aimed to evaluate the risk factors associated with depression, anxiety and health-related quality of life (HRQoL) in paediatric iGCT survivors. METHODS: We recruited 200 iGCT patients (and their parents) from Beijing Tiantan Hospital and assessed their HRQoL using the Paediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales. The Children’s Depression Inventory, Screen for Child Anxiety Related Emotional Disorders, and Symptom Checklist 90 were used to evaluate depression and anxiety. The results were analysed based on disease recurrence, tumour location and treatment strategies. RESULTS: Survivors with recurrent tumours had worse HRQoL scores than those with non-recurrent tumours. Patients with tumours involving both the suprasellar and basal ganglia regions had the worst HRQoL scores. A large proportion of survivors had depression or anxiety. Both depression and anxiety scores were highly correlated with the HRQoL emotional functioning scores. The parent proxy-reports (PPR) and child self-reports were highly correlated in all domains. CONCLUSIONS: This study demonstrated the clinical factors affecting paediatric iGCT survivors’ depression, anxiety, and HRQoL. Therefore, psychological interventions should be implemented. It also suggests that the PedsQL PPR would be helpful for routine screening. |
format | Online Article Text |
id | pubmed-8753919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87539192022-01-18 Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors Lv, Wenyi Li, Bo Feng, Jin Chen, Li Qiu, Xiaoguang Liu, Shuai Health Qual Life Outcomes Research BACKGROUND: Little is known about depression and anxiety among paediatric intracranial germ cell tumour (iGCT) survivors. We aimed to evaluate the risk factors associated with depression, anxiety and health-related quality of life (HRQoL) in paediatric iGCT survivors. METHODS: We recruited 200 iGCT patients (and their parents) from Beijing Tiantan Hospital and assessed their HRQoL using the Paediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales. The Children’s Depression Inventory, Screen for Child Anxiety Related Emotional Disorders, and Symptom Checklist 90 were used to evaluate depression and anxiety. The results were analysed based on disease recurrence, tumour location and treatment strategies. RESULTS: Survivors with recurrent tumours had worse HRQoL scores than those with non-recurrent tumours. Patients with tumours involving both the suprasellar and basal ganglia regions had the worst HRQoL scores. A large proportion of survivors had depression or anxiety. Both depression and anxiety scores were highly correlated with the HRQoL emotional functioning scores. The parent proxy-reports (PPR) and child self-reports were highly correlated in all domains. CONCLUSIONS: This study demonstrated the clinical factors affecting paediatric iGCT survivors’ depression, anxiety, and HRQoL. Therefore, psychological interventions should be implemented. It also suggests that the PedsQL PPR would be helpful for routine screening. BioMed Central 2022-01-12 /pmc/articles/PMC8753919/ /pubmed/35022038 http://dx.doi.org/10.1186/s12955-021-01911-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lv, Wenyi Li, Bo Feng, Jin Chen, Li Qiu, Xiaoguang Liu, Shuai Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
title | Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
title_full | Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
title_fullStr | Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
title_full_unstemmed | Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
title_short | Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
title_sort | depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753919/ https://www.ncbi.nlm.nih.gov/pubmed/35022038 http://dx.doi.org/10.1186/s12955-021-01911-9 |
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