The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells

Under oxidative stress, viruses prefer glycolysis as an ATP source, and glutamine is required as an anaplerotic substrate to replenish the TCA cycle. Infectious spleen and kidney necrosis virus (ISKNV) induces reductive glutamine metabolism in the host cells. Here we report that ISKNV infection the...

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Detalles Bibliográficos
Autores principales: Fu, Xiaozhe, Li, Kejin, Niu, Yinjie, Lin, Qiang, Liang, Hongru, Luo, Xia, Liu, Lihui, Li, Ningqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754121/
https://www.ncbi.nlm.nih.gov/pubmed/35019690
http://dx.doi.org/10.1128/spectrum.02310-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754121/
https://www.ncbi.nlm.nih.gov/pubmed/35019690
http://dx.doi.org/10.1128/spectrum.02310-21

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