In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus

The aminobenzimidazole SPR719 targets DNA gyrase in Mycobacterium tuberculosis. The molecule acts as inhibitor of the enzyme’s ATPase located on the Gyrase B subunit of the tetrameric Gyrase A(2)B(2) protein. SPR719 is also active against non-tuberculous mycobacteria (NTM) and recently entered clini...

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Detalles Bibliográficos
Autores principales: Aragaw, Wassihun Wedajo, Cotroneo, Nicole, Stokes, Suzanne, Pucci, Michael, Critchley, Ian, Gengenbacher, Martin, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754139/
https://www.ncbi.nlm.nih.gov/pubmed/35019671
http://dx.doi.org/10.1128/spectrum.01321-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754139/
https://www.ncbi.nlm.nih.gov/pubmed/35019671
http://dx.doi.org/10.1128/spectrum.01321-21

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