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Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development

Cortical interneuron neurogenesis is strictly regulated and depends on the presence of thyroid hormone (TH). In particular, inhibitory interneurons expressing the calcium binding protein Parvalbumin are highly sensitive toward developmental hypothyroidism. Reduced numbers of Parvalbumin-positive int...

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Detalles Bibliográficos
Autores principales: Mayerl, Steffen, Chen, Jiesi, Salveridou, Eva, Boelen, Anita, Darras, Veerle M, Heuer, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754375/
https://www.ncbi.nlm.nih.gov/pubmed/34339499
http://dx.doi.org/10.1093/cercor/bhab211