Nuclear NAD(+)-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD(+) homeostasis for health and function, the specific roles of subcellular NAD(+) pools in retinal development, maintenance, and disease remain obscure. Here, we show that deletion of the nuclear-localized NAD(...

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Detalles Bibliográficos
Autores principales: Sokolov, David, Sechrest, Emily R, Wang, Yekai, Nevin, Connor, Du, Jianhai, Kolandaivelu, Saravanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754432/
https://www.ncbi.nlm.nih.gov/pubmed/34878972
http://dx.doi.org/10.7554/eLife.71185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754432/
https://www.ncbi.nlm.nih.gov/pubmed/34878972
http://dx.doi.org/10.7554/eLife.71185

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