Cargando…

Nuclear NAD(+)-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD(+) homeostasis for health and function, the specific roles of subcellular NAD(+) pools in retinal development, maintenance, and disease remain obscure. Here, we show that deletion of the nuclear-localized NAD(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sokolov, David, Sechrest, Emily R, Wang, Yekai, Nevin, Connor, Du, Jianhai, Kolandaivelu, Saravanan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754432/ https://www.ncbi.nlm.nih.gov/pubmed/34878972 http://dx.doi.org/10.7554/eLife.71185

Ejemplares similares

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
por: Rossi, Francesca, et al.
Publicado: (2018)

A Modified Acyl-RAC Method of Isolating Retinal Palmitoyl Proteome for Subsequent Detection through LC-MS/MS
por: Motipally, Sree I., et al.
Publicado: (2023)

Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo
por: Yamamoto, Masashi, et al.
Publicado: (2016)

Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells
por: Shi, Xiangguo, et al.
Publicado: (2021)

Expression of NMNAT1 in the photoreceptors is sufficient to prevent NMNAT1-associated retinal degeneration
por: Brown, Emily E., et al.
Publicado: (2023)

Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7
por: Chen, Hao, et al.
Publicado: (2015)

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity
por: Zhai, R. Grace, et al.
Publicado: (2006)

NMNAT2‐mediated NAD(+) generation is essential for quality control of aged oocytes
por: Wu, Xinghan, et al.
Publicado: (2019)

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion
por: Sasaki, Yo, et al.
Publicado: (2016)

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
por: Yang, Sen, et al.
Publicado: (2023)

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons
por: Ali, Yousuf O., et al.
Publicado: (2017)

Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age‐associated insulin resistance
por: Gulshan, Maryam, et al.
Publicado: (2018)

Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
por: Lavado-Roldán, Angela, et al.
Publicado: (2016)

Corrigendum: Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons
por: Ali, Yousuf O., et al.
Publicado: (2017)

Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria
por: Felici, Roberta, et al.
Publicado: (2013)

Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway
por: Parsons, Richard B, et al.
Publicado: (2022)

The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions
por: Fortunato, Carlo, et al.
Publicado: (2021)

R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization
por: Myers, Boyden, et al.
Publicado: (2022)

Correction: Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria
por: Felici, Roberta, et al.
Publicado: (2013)

Loss of PRCD alters number and packaging density of rhodopsin in rod photoreceptor disc membranes
por: Sechrest, Emily R., et al.
Publicado: (2020)

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer
por: Audrito, Valentina, et al.
Publicado: (2019)

Gene Therapy Preserves Retinal Structure and Function in a Mouse Model of NMNAT1-Associated Retinal Degeneration
por: Greenwald, Scott H., et al.
Publicado: (2020)

SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
por: Sasaki, Yo, et al.
Publicado: (2020)

Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues
por: Mori, Valerio, et al.
Publicado: (2014)

De novo NAD+ biosynthetic impairment in acute kidney injury in humans
por: Mehr, Ali Poyan, et al.
Publicado: (2018)

Why is NMNAT Protective against Neuronal Cell Death and Axon Degeneration, but Inhibitory of Axon Regeneration?
por: Tang, Bor Luen
Publicado: (2019)

Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD(+)-Sirt3 pathway
por: Wang, Tao, et al.
Publicado: (2022)

NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health
por: Campagna, Roberto, et al.
Publicado: (2023)

NMNAT1 mutations cause Leber congenital amaurosis
por: Falk, Marni J, et al.
Publicado: (2012)

Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development
por: Kuribayashi, Hiroshi, et al.
Publicado: (2022)

Neuronal NMNAT2 Overexpression Does Not Achieve Significant Neuroprotection in Experimental Autoimmune Encephalomyelitis/Optic Neuritis
por: Liu, Pingting, et al.
Publicado: (2021)

Novel NAD(+)-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant
por: Seman-Kamarulzaman, Ahmad-Faris, et al.
Publicado: (2016)

Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States
por: Saravanan, Meghashri, et al.
Publicado: (2023)

YUCCA auxin biosynthetic genes are required for Arabidopsis shade avoidance
por: Müller-Moulé, Patricia, et al.
Publicado: (2016)

Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation
por: Kuribayashi, Hiroshi, et al.
Publicado: (2018)

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
por: Ali, Yousuf O., et al.
Publicado: (2016)

Nmnat1 protects neuronal function without altering phospho‐tau pathology in a mouse model of tauopathy
por: Musiek, Erik S., et al.
Publicado: (2016)

Decreased NAD+ in dopaminergic neurons
por: Sison, Samantha L., et al.
Publicado: (2018)

Identification of Palmitoyltransferase and Thioesterase Enzymes That Control the Subcellular Localization of Axon Survival Factor Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2)
por: Milde, Stefan, et al.
Publicado: (2014)

Farnesylation of the Transducin G Protein Gamma Subunit Is a Prerequisite for Its Ciliary Targeting in Rod Photoreceptors
por: Brooks, Celine, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nu69pkmmkqarh6dpq7ck79dkfm