Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates

The identification of nonenzymatic pathways for nucleic acid replication is a key challenge in understanding the origin of life. We have previously shown that nonenzymatic RNA primer extension using 2-aminoimidazole (2AI) activated nucleotides occurs primarily through an imidazolium-bridged dinucleo...

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Detalles Bibliográficos
Autores principales: Ding, Dian, Zhou, Lijun, Giurgiu, Constantin, Szostak, Jack W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754633/
https://www.ncbi.nlm.nih.gov/pubmed/34893864
http://dx.doi.org/10.1093/nar/gkab1202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754633/
https://www.ncbi.nlm.nih.gov/pubmed/34893864
http://dx.doi.org/10.1093/nar/gkab1202

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