Multiplexed activation in mammalian cells using a split-intein CRISPR/Cas12a based synthetic transcription factor

The adoption of CRISPR systems for the generation of synthetic transcription factors has greatly simplified the process for upregulating endogenous gene expression, with a plethora of applications in cell biology, bioproduction and cell reprogramming. The recently discovered CRISPR/Cas12a (Cas12a) s...

Descripción completa

Detalles Bibliográficos
Autores principales: Bryson, James W, Auxillos, Jamie Y, Rosser, Susan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754635/
https://www.ncbi.nlm.nih.gov/pubmed/34908140
http://dx.doi.org/10.1093/nar/gkab1191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754635/
https://www.ncbi.nlm.nih.gov/pubmed/34908140
http://dx.doi.org/10.1093/nar/gkab1191

Ejemplares similares