Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides

Tricyclo-DNA (tcDNA) is a conformationally constrained oligonucleotide analog that has demonstrated great therapeutic potential as antisense oligonucleotide (ASO) for several diseases. Like most ASOs in clinical development, tcDNA were modified with phosphorothioate (PS) backbone for therapeutic pur...

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Detalles Bibliográficos
Autores principales: Relizani, Karima, Echevarría, Lucía, Zarrouki, Faouzi, Gastaldi, Cécile, Dambrune, Chloe, Aupy, Philippine, Haeberli, Adrian, Komisarski, Marek, Tensorer, Thomas, Larcher, Thibaut, Svinartchouk, Fedor, Vaillend, Cyrille, Garcia, Luis, Goyenvalle, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754652/
https://www.ncbi.nlm.nih.gov/pubmed/34893881
http://dx.doi.org/10.1093/nar/gkab1199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754652/
https://www.ncbi.nlm.nih.gov/pubmed/34893881
http://dx.doi.org/10.1093/nar/gkab1199

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