Rational design and construction of multi-copy biomanufacturing islands in mammalian cells

Cell line development is a critical step in the establishment of a biopharmaceutical manufacturing process. Current protocols rely on random transgene integration and amplification. Due to considerable variability in transgene integration profiles, this workflow results in laborious screening campai...

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Detalles Bibliográficos
Autores principales: Altamura, Raffaele, Doshi, Jiten, Benenson, Yaakov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754653/
https://www.ncbi.nlm.nih.gov/pubmed/34893882
http://dx.doi.org/10.1093/nar/gkab1214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754653/
https://www.ncbi.nlm.nih.gov/pubmed/34893882
http://dx.doi.org/10.1093/nar/gkab1214

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