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Rational design and construction of multi-copy biomanufacturing islands in mammalian cells
Cell line development is a critical step in the establishment of a biopharmaceutical manufacturing process. Current protocols rely on random transgene integration and amplification. Due to considerable variability in transgene integration profiles, this workflow results in laborious screening campai...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754653/ https://www.ncbi.nlm.nih.gov/pubmed/34893882 http://dx.doi.org/10.1093/nar/gkab1214 |