A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

Polo-like kinase 1 (PLK1) is a crucial regulator of cell cycle progression. It is established that the activation of PLK1 depends on the coordinated action of Aurora-A and Bora. Nevertheless, very little is known about the spatiotemporal regulation of PLK1 during G2, specifically, the mechanisms tha...

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Detalles Bibliográficos
Autores principales: Raab, Monika, Matthess, Yves, Raab, Christopher A., Gutfreund, Niklas, Dötsch, Volker, Becker, Sven, Sanhaji, Mourad, Strebhardt, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755526/
https://www.ncbi.nlm.nih.gov/pubmed/34759346
http://dx.doi.org/10.1038/s41388-021-02094-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755526/
https://www.ncbi.nlm.nih.gov/pubmed/34759346
http://dx.doi.org/10.1038/s41388-021-02094-9

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