NR1D1 regulation by Ran GTPase via miR4472 identifies an essential vulnerability linked to aneuploidy in ovarian cancer

While aneuploidy is a main enabling characteristic of cancers, it also creates specific vulnerabilities. Here we demonstrate that Ran inhibition targets epithelial ovarian cancer (EOC) survival through its characteristic aneuploidy. We show that induction of aneuploidy in rare diploid EOC cell lines...

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Detalles Bibliográficos
Autores principales: Boudhraa, Zied, Zaoui, Kossay, Fleury, Hubert, Cahuzac, Maxime, Gilbert, Sophie, Tchakarska, Guergana, Kendall-Dupont, Jennifer, Carmona, Euridice, Provencher, Diane, Mes-Masson, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755527/
https://www.ncbi.nlm.nih.gov/pubmed/34743206
http://dx.doi.org/10.1038/s41388-021-02082-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755527/
https://www.ncbi.nlm.nih.gov/pubmed/34743206
http://dx.doi.org/10.1038/s41388-021-02082-z

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