HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51

DNA double-stranded breaks (DSBs) are deleterious lesions, and their incorrect repair can drive cancer development(1). HELQ is a superfamily 2 helicase with 3′ to 5′ polarity, and its disruption in mice confers germ cells loss, infertility and increased predisposition to ovarian and pituitary tumour...

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Detalles Bibliográficos
Autores principales: Anand, Roopesh, Buechelmaier, Erika, Belan, Ondrej, Newton, Matthew, Vancevska, Aleksandra, Kaczmarczyk, Artur, Takaki, Tohru, Rueda, David S., Powell, Simon N., Boulton, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755542/
https://www.ncbi.nlm.nih.gov/pubmed/34937945
http://dx.doi.org/10.1038/s41586-021-04261-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755542/
https://www.ncbi.nlm.nih.gov/pubmed/34937945
http://dx.doi.org/10.1038/s41586-021-04261-0

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