Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

BACKGROUND: Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. METHODS: We obtained the lung specimens from the patients who died of COVID-19. The phenotype...

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Detalles Bibliográficos
Autores principales: Won, Taejoon, Wood, Megan K., Hughes, David M., Talor, Monica V., Ma, Zexu, Schneider, Jowaly, Skinner, John T., Asady, Beejan, Goerlich, Erin, Halushka, Marc K., Hays, Allison G., Kim, Deok-Ho, Parikh, Chirag R., Rosenberg, Avi Z., Coppens, Isabelle, Johns, Roger A., Gilotra, Nisha A., Hooper, Jody E., Pekosz, Andrew, Čiháková, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756077/
https://www.ncbi.nlm.nih.gov/pubmed/35033854
http://dx.doi.org/10.1016/j.ebiom.2022.103812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756077/
https://www.ncbi.nlm.nih.gov/pubmed/35033854
http://dx.doi.org/10.1016/j.ebiom.2022.103812

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