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Site-Specific DNA Demethylation as a Potential Target for Cancer Epigenetic Therapy
Aberrant promoter DNA hypermethylation is a typical characteristic of cancer and it is often seen in malignancies. Recent studies showed that regulatory cis-elements found up-stream of many tumor suppressor gene promoter CpG island (CGI) attract DNA methyltransferases (DNMT) that hypermethylates and...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756105/ https://www.ncbi.nlm.nih.gov/pubmed/35036833 http://dx.doi.org/10.1177/2516865720964808 |