Detection of TERT Promoter Mutations Using Targeted Next-Generation Sequencing: Overcoming GC Bias through Trial and Error

PURPOSE: Detection of telomerase reverse transcriptase (TERT) promoter mutations is a crucial process in the integrated diagnosis of glioblastomas. However, the TERT promoter region is difficult to amplify because of its high guanine-cytosine (GC) content (> 80%). This study aimed to analyze the...

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Detalles Bibliográficos
Autores principales: Lee, Hyunwoo, Lee, Boram, Kim, Deok Geun, Cho, Yoon Ah, Kim, Jung-Sun, Suh, Yeon-Lim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756133/
https://www.ncbi.nlm.nih.gov/pubmed/33940787
http://dx.doi.org/10.4143/crt.2021.107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8756133/
https://www.ncbi.nlm.nih.gov/pubmed/33940787
http://dx.doi.org/10.4143/crt.2021.107

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